Product Name | NFκB-p105(Phospho-Ser893) Antibody |
Host Species | Rabbit |
Clonality | Polyclonal |
Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Applications | IHC IF |
Reactivity | Hu Ms Rt |
Specificity | The antibody detects endogenous level of total NFkB-p105 protein. |
Immunogen | Peptide-KLH. Peptide sequence around aa.891~895 (A-S-S-P-V) derived from Human NFκB-p105. |
Target Name | NFκB-p105 |
Alternative Name | KBF1; NF-kB1; NFkappaB |
Modification | Phospho-Ser893 |
SDS-PAGE MW | 120kd |
Accession No | P19838; NP_001158884.1 |
Concentration | 1.0mg/ml |
Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage | Store at -20°C. |
Application
Background
Background
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.